Genetic Based Supplementation For Masculine Aging

Dr. Panzner reveals how commonly recommended supplements can unknowingly interfere with hormone optimisation, highlighting the importance of understanding supplement mechanisms beyond their marketed benefits.

Key Takeaways:

The Supplement Iceberg Effect

• Most supplements have multiple mechanisms beyond their marketed benefits
• What's on the label is often just "the tip of the iceberg"
• The same supplement can help one person whilst harming another
• Many popular supplements can lower DHT and testosterone

Common DHT-Lowering Supplements

• Lion's Mane Mushroom
• Reishi Mushroom
• Green Tea Extract
• Curcumin/Turmeric
• Saw Palmetto
• Concentrated versions can be particularly problematic

Risk Assessment Framework

• Men with full heads of hair likely have normal/low DHT
• Those with male pattern baldness likely have higher DHT
• Risk of DHT-lowering supplements varies based on starting point
• Concentrated supplements amplify both benefits and risks

Critical Pathways for Optimisation

• Methylation status (measured via homocysteine)
• Vitamin D levels (optimal range 50-70 ng/mL)
• Both should be optimised before considering hormone therapy
• Genetic variations affect individual needs

Pre-Testosterone Considerations

• Check pregnenolone and DHEA levels
• Assess vitamin D co-factors (magnesium, boron, K2)
• Consider genetic testing for hormone pathways
• Address methylation issues first

Practical Implications:

• Avoid multi-ingredient supplements without understanding mechanisms
• Be cautious with concentrated/"enhanced" supplement versions
• Consider genetic testing before extensive supplementation
• Work with practitioners who understand supplement pharmacology

Warning Signs:

• Taking multiple supplements that affect DHT
• Using highly concentrated extracts
• Following protocols without individualisation
• Experiencing unexplained mood/energy changes on supplements

The information, content, and materials presented during here are for informational and educational purposes only. They do not constitute medical advice, diagnosis, or treatment, and should not be considered a substitute for professional medical consultation, diagnosis, or treatment.